该剧改编自藤萍的小说《吉祥纹莲花楼》。讲述了闻名武林的四顾门门主李相夷（成毅饰）在一次大战后身受重伤，从此退隐江湖成为淡泊名利的“假神医”李莲花，在遇到新交方多病与旧敌笛飞声后重新卷入江湖的故事。江湖暗流涌动，疑团扑朔迷离，抽丝剥茧方能断出真相，一段荡气回肠的侠义情即将热血展开。
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